Combinatorial biaryl amino acid amide libraries
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United States of America Patent
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Sep 7, 1999
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N/A
app pub date -
Jun 16, 1997
filing date -
Jun 16, 1997
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Abstract
Combinatorial chemical libraries of the Formula ?S!-C(O)-L'-Z containing biaryl amino acids are disclosed, in which ?S! represents a solid support and -L'-Z is a linker/compound residue. In these libraries, Z is --NR.sup.1 R.sup.2. R.sup.1 is chosen from H, C.sub.1 to C.sub.20 hydrocarbon, heteroaralkyl, heterocycloalkyl, substituted arylalkyl, alkoxyalkyl or alkyl-SO.sub.2 NH-alkyl and R.sup.4 is an acyl or sulfonyl residue. R.sup.2 is chosen from ##STR1## The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.
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