Microemulsion preparation containing a slightly absorbable substance
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United States of America Patent
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Sep 7, 1999
Grant Date -
N/A
app pub date -
Oct 19, 1995
filing date -
Apr 19, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Microemulsion preparation in which a plurality of specified surfactants are combined such that aqueous-phase droplets that contain a physiologically active substance of low absorption and which have an average size of 0.4-100 nm are dispersed in an oil-phase dispersion medium. In order to improve its low transdermic or transmucosal absorbability, the physiologically active substance is allowed to be present as dissolved in the aqueous-phase droplets in the W/O emulsion. The preparation is low in local irritation and uses neither malodorous substances such as higher alcohols nor conventional absorption enhancers.
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