Antisense oligonucleotides for aromatase inhibition
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United States of America Patent
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Sep 7, 1999
Grant Date -
N/A
app pub date -
Aug 13, 1996
filing date -
Jun 24, 1994
priority date (Note) -
Expired
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Abstract
The invention relates to an antisense oligonucleotide suitable for inhibiting the expression of aromatase, the antisense oligonucleotide being obtainable by the following steps: (a) construction of antisense oligonucleotides along the entire length of coding and regulatory regions of an aromatase DNA and/or transcripts thereof, the antisense oligonucleotides overlapping; (b) incubation of an aromatase-expressing cell with one or more of the antisense oligonucleotides of (a); and (c) detection of the inhibition of the aromatase expression as usual, as well as identification of the antisense oligonucleotide(s) responsible for this. Furthermore, the invention relates to a process for preparing such an antisense oligonucleotides as well as its use.
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