US Patent No: 5,954,706

Number of patents in Portfolio can not be more than 2000

Drug delivery

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC CORPORATIONMAPLE GROVE, MN335

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sahatjian, Ronald A Lexington, MA 114 4116

Cited Art Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (5)
4,994,033 Intravascular drug delivery dilatation catheter 390 1989
5,047,045 Multi-section coaxial angioplasty catheter 184 1989
5,135,516 Lubricious antithrombogenic catheters, guidewires and coatings 228 1989
5,304,121 Drug delivery system making use of a hydrogel polymer coating 510 1991
5,234,456 Hydrophilic stent 508 1992
 
CORDIS CORPORATION (3)
5,041,100 Catheter and hydrophilic, friction-reducing coating thereon 153 1989
5,049,132 Balloon catheter for delivering therapeutic agents 385 1990
5,213,576 Therapeutic porous balloon catheter 273 1991
 
TERUMO KABUSHIKI KAISHA (2)
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Adams and Reese LLP (1)
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ADVANCED CARDIOVASCULAR SYSTEMS, INC. (1)
5,021,044 Catheter for even distribution of therapeutic fluids 226 1989
 
Baxter Travenol Laboratories, Inc. (1)
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BECTON, DICKINSON AND COMPANY (1)
4,589,873 Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby 98 1984
 
C.R. BARD, INC. (1)
4,515,593 Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same 87 1981
 
DEVICE DEVELOPMENTS, INC. (1)
4,448,195 Reinforced balloon catheter 95 1981
 
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GENZYME CORPORATION (1)
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Hydromer, Inc. (1)
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KABUSHIKI KAISHA TAIKI (1)
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Lathrotec, Inc. (1)
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LUTHER MEDICAL PRODUCTS, INC. (1)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
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MEDICAL RESEARCH ASSOCIATES, LTD., #2, 12707 U.S. 19 SOUTH CLEARWATER, FLA. 33516 A LIMITED PARTNERSHIP OF FLA. (1)
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MEDTRONIC AVE, INC. (1)
5,026,607 Medical apparatus having protective, lubricious coating 141 1989
 
MEDTRONIC, INC. (1)
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Schneider (Europe) A.G. (1)
5,163,906 Dilatation catheter and method for widening of strictures 120 1992
 
SHERWOOD SERVICES AG (1)
4,330,497 Method of making grooved plastic medical tubing 56 1981
 
The Beth Israel Hospital Association (1)
4,909,258 Internal mammary artery (IMA) catheter 98 1988
 
The Kendall Company (1)
4,784,647 Catheter meatal pad device 44 1986
 
UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (1)
5,091,205 Hydrophilic lubricious coatings 318 1989
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
4,364,392 Detachable balloon catheter 166 1980
 
Other [Check patent profile for assignment information] (8)
4,299,226 Coronary dilation method 204 1979
4,423,725 Multiple surgical cuff 443 1982
4,592,340 Artificial catheter means 245 1984
4,693,243 Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas 124 1986
4,820,270 Balloon catheter and process for the manufacture thereof 74 1987
4,983,166 Balloon catheter and method of use of the same 56 1990
5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 185 1990
5,232,444 Dilatation catheter 273 1991

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (58)
6,613,025 Method and apparatus for diagnostic and therapeutic agent delivery 14 2000
8,211,455 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 0 2002
7,939,094 Multiphase polymeric drug release region 6 2002
7,105,175 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 28 2002
7,060,051 Multi-balloon catheter with hydrogel coating 74 2002
7,066,904 Triggered release hydrogel drug delivery system 39 2002
7,491,234 Medical devices for delivery of therapeutic agents 18 2002
8,313,759 Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent 0 2003
7,241,455 Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent 18 2003
7,762,996 Method and apparatus for diagnostic and therapeutic agent delivery 2 2003
7,914,805 Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent 0 2003
7,357,940 Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents 6 2003
8,840,660 Bioerodible endoprostheses and methods of making the same 0 2006
8,089,029 Bioabsorbable metal medical device and method of manufacture 1 2006
8,187,620 Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents 1 2006
8,048,150 Endoprosthesis having a fiber meshwork disposed thereon 2 2006
8,815,275 Coatings for medical devices comprising a therapeutic agent and a metallic material 0 2006
7,901,702 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 0 2006
8,067,054 Stents with ceramic drug reservoir layer and methods of making and using the same 2 2007
7,976,915 Endoprosthesis with select ceramic morphology 1 2007
8,771,343 Medical devices with selective titanium oxide coatings 0 2007
7,381,418 Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent 18 2007
8,002,823 Endoprosthesis coating 1 2007
7,942,926 Endoprosthesis coating 1 2007
8,815,273 Drug eluting medical devices having porous layers 0 2007
7,931,683 Articles having ceramic coated surfaces 15 2007
8,052,743 Endoprosthesis with three-dimensional disintegration control 1 2007
8,353,949 Medical devices with drug-eluting coating 1 2007
8,052,744 Medical devices and methods of making the same 2 2007
8,052,745 Endoprosthesis 0 2007
8,002,821 Bioerodible metallic ENDOPROSTHESES 3 2007
8,808,726 Bioerodible endoprostheses and methods of making the same 0 2007
8,128,689 Bioerodible endoprosthesis with biostable inorganic layers 1 2007
8,057,534 Bioerodible endoprostheses and methods of making the same 6 2007
7,981,150 Endoprosthesis with coatings 7 2007
8,216,632 Endoprosthesis coating 0 2007
8,029,554 Stent with embedded material 3 2007
7,938,855 Deformable underlayer for stent 2 2007
8,080,055 Bioerodible endoprostheses and methods of making the same 0 2007
8,431,149 Coated medical devices for abluminal drug delivery 1 2008
8,070,797 Medical device with a porous surface for delivery of a therapeutic agent 3 2008
7,998,192 Endoprostheses 3 2008
8,236,046 Bioerodible endoprosthesis 0 2008
8,221,822 Medical device coating by laser cladding 0 2008
7,985,252 Bioerodible endoprosthesis 4 2008
8,333,795 Bulging balloon for bifurcation catheter assembly and methods 0 2008
8,382,824 Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides 0 2008
8,361,143 Medical devices for delivery of therapeutic agents 0 2009
8,071,156 Endoprostheses 1 2009
8,287,937 Endoprosthese 1 2009
8,449,603 Endoprosthesis coating 1 2009
8,231,980 Medical implants including iridium oxide 0 2009
8,267,992 Self-buffering medical implants 0 2010
8,066,763 Drug-releasing stent with ceramic-containing layer 0 2010
8,574,615 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 0 2010
8,668,732 Surface treated bioerodible metal endoprostheses 0 2011
8,669,360 Methods of converting amorphous drug substance into crystalline form 0 2011
8,715,339 Bioerodible endoprostheses and methods of making the same 0 2011
 
COVIDIEN LP (19)
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8,196,584 Endotracheal cuff and technique for using the same 1 2006
8,684,175 Method for shipping and protecting an endotracheal tube with an inflated cuff 0 2006
8,561,614 Multi-layer cuffs for medical devices 0 2006
8,307,830 Endotracheal cuff and technique for using the same 0 2006
7,950,393 Endotracheal cuff and technique for using the same 0 2006
8,257,722 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 2 2008
8,750,978 System and sensor for early detection of shock or perfusion failure and technique for using the same 0 2008
8,590,534 Cuff for use with medical tubing and method and apparatus for making the same 0 2009
8,128,951 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 2 2010
8,114,429 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 2 2010
8,413,659 Self-sizing adjustable endotracheal tube 0 2010
8,813,750 Self-sizing adjustable endotracheal tube 0 2010
8,807,136 Self-sizing adjustable endotracheal tube 0 2010
8,563,023 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2011
8,491,925 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 2 2011
8,673,332 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2012
8,636,010 Endotracheal cuff and technique for using the same 0 2012
8,734,825 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2013
 
LUTONIX, INC. (10)
8,414,909 Drug releasing coatings for medical devices 0 2007
8,414,525 Drug releasing coatings for medical devices 0 2008
8,425,459 Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent 0 2008
8,414,526 Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids 2 2008
8,430,055 Methods and apparatuses for coating balloon catheters 0 2009
8,414,910 Drug releasing coatings for medical devices 1 2010
8,403,910 Drug releasing coatings for medical devices 0 2011
8,404,300 Drug releasing coatings for medical devices 0 2011
8,366,660 Drug releasing coatings for medical devices 0 2011
8,366,662 Drug releasing coatings for medical devices 0 2011
 
VITAL ACCESS CORPORATION (5)
6,656,151 Vascular access devices and systems 19 2000
6,595,941 Methods for external treatment of blood 18 2000
6,663,590 Vascular occlusal balloons and related vascular access devices and systems 33 2001
7,131,959 Apparatus and methods for occluding an access tube anastomosed to sidewall of an anatomical vessel 9 2003
7,124,570 Apparatus and methods for fluid occlusion of an access tube anastomosed to an anatomical vessel 9 2003
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (4)
8,226,603 Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 1 2008
8,049,061 Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery 0 2008
8,076,529 Expandable member formed of a fibrous matrix for intraluminal drug delivery 0 2008
8,500,687 Stent delivery system having a fibrous matrix covering with improved stent retention 0 2011
 
Biosynergetics, Inc. (4)
6,738,661 Apparatus and methods for the controllable modification of compound concentration in a tube 10 2000
7,616,989 Manufacturing methods for an apparatus for the controllable modification of compound concentration in a tube 0 2001
6,985,770 Apparatus for the controllable modification of compound concentration in a tube 7 2001
8,317,760 Apparatus and methods for the controllable modification of compound concentration in a tube 0 2007
 
C.R. BARD, INC. (4)
8,337,475 Corporeal drainage system 2 2005
8,177,772 Catheter connection systems 6 2006
8,235,971 Catheter connection systems 7 2010
8,814,839 Corporeal drainage system 0 2012
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
8,172,783 Conduit system for isolation of fluids in biological tissues 0 1999
7,481,790 Vessel enlargement by arteriogenic factor delivery 1 2000
8,277,436 Vessel enlargement by arteriogenic factor delivery 0 2008
 
COOK MEDICAL TECHNOLOGIES LLC (3)
8,172,793 Coated medical device 3 2005
8,673,387 Coated medical device 0 2009
8,469,943 Coated implantable medical device 0 2010
 
BATTELLE MEMORIAL INSTITUTE (2)
6,979,464 Reversible geling co-polymer and method of making 8 1998
7,033,571 Multiple stimulus reversible hydrogels 21 2003
 
BAYER INTELLECTUAL PROPERTY GMBH (2)
8,439,868 Medical device for dispersing medicaments 0 2010
8,389,043 Preparation for restenosis prevention 0 2010
 
BIOCOMPATIBLES UK LIMITED (2)
6,746,686 Coated implants 23 2001
6,872,225 Local drug delivery 10 2002
 
CYTYC CORPORATION (2)
6,200,257 Catheter with permeable hydrogel membrane 93 1999
6,537,194 Catheter with permeable hydrogel membrane 28 2000
 
ETHICON, INC. (2)
6,808,518 Methods and devices for treating diseased blood vessels 21 2001
7,611,484 Methods and devices for treating diseased blood vessels 9 2004
 
ULRICH SPECK (2)
7,750,041 Preparation for the prophylaxis of restenosis 5 2001
8,257,305 Medical device for dispensing medicaments 0 2003
 
ARROWHEAD MADISON INC. (1)
6,379,966 Intravascular delivery of non-viral nucleic acid 11 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
7,238,199 Method and apparatus for stent deployment with enhanced delivery of bioactive agents 47 2002
 
BOSTON SCIENTIFIC CORPORATION (1)
7,291,110 Catheter lesion diagnostics 5 2002
 
FLUGEN, INC. (1)
8,668,675 Wearable drug delivery device having spring drive and sliding actuation mechanism 0 2011
 
HEMOTEQ AG (1)
8,597,720 Medical product for treating stenosis of body passages and for preventing threatening restenosis 0 2008
 
INTEGRATED VASCULAR INTERVENTIONAL TECHNOLOGIES (1)
7,118,546 Apparatus and methods for facilitating repeated vascular access 11 2003
 
MICRO THERAPEUTICS, INC. (1)
6,635,027 Method and apparatus for intramural delivery of a substance 32 2000
 
ORBUSNEICH MEDICAL, INC. (1)
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Pentech Medical Devices Ltd. (1)
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REMON MEDICAL TECHNOLOGIES LTD. (1)
8,303,643 Method and device for electrochemical formation of therapeutic species in vivo 0 2010
 
SCIMED LIFE SYSTEMS, INC. (1)
6,409,716 Drug delivery 117 1997
 
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (1)
8,636,721 Portable hand pump for evacuation of fluids 1 2004
 
Other [Check patent profile for assignment information] (3)
7,226,473 Treatment of stenotic regions 5 2003
8,211,085 Therapeutic device for the selective cytoreduction treatment of an obstruction in a natural lumen or passage of the human or animal body 0 2004
7,468,052 Treatment of stenotic regions 0 2007