US Patent No: 5,954,706

Number of patents in Portfolio can not be more than 2000

Drug delivery

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ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC CORPORATIONMAPLE GROVE, MN333

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sahatjian, Ronald A Lexington, MA 95 3257

Cited Art

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (5)
4,994,033 Intravascular drug delivery dilatation catheter 335 1989
5,047,045 Multi-section coaxial angioplasty catheter 171 1989
5,135,516 Lubricious antithrombogenic catheters, guidewires and coatings 192 1989
5,304,121 Drug delivery system making use of a hydrogel polymer coating 422 1991
5,234,456 Hydrophilic stent 440 1992
 
CORDIS CORPORATION (3)
5,041,100 Catheter and hydrophilic, friction-reducing coating thereon 137 1989
5,049,132 Balloon catheter for delivering therapeutic agents 358 1990
5,213,576 Therapeutic porous balloon catheter 233 1991
 
TERUMO KABUSHIKI KAISHA (2)
4,832,688 Catheter for repair of blood vessel 176 1987
4,876,126 Medical instrument and method for making 109 1988
 
ADAMS AND REESE LLP (1)
4,714,460 Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency 163 1986
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (1)
5,021,044 Catheter for even distribution of therapeutic fluids 205 1989
 
ALLEGIANCE CORPORATION (1)
4,603,152 Antimicrobial compositions 168 1984
 
BECTON, DICKINSON AND COMPANY (1)
4,589,873 Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby 88 1984
 
C.R. BARD, INC. (1)
4,515,593 Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same 78 1981
 
DEVICE DEVELOPMENTS, INC. (1)
4,448,195 Reinforced balloon catheter 90 1981
 
ECLIPSE SURGICAL TECHNOLOGIES, INC. (1)
4,993,412 Method and apparatus for removal of obstructive substance from body channels 34 1989
 
GENZYME CORPORATION (1)
5,213,580 Biodegradable polymeric endoluminal sealing process 259 1992
 
HYDROMER, INC. (1)
4,769,013 Bio-effecting medical material and device 130 1986
 
KABUSHIKI KAISHA TAIKI (1)
4,923,450 Medical tubes for placement into the body of a patient 115 1988
 
LATHROTEC, INC. (1)
5,120,322 Method and apparatus for treatment of fibrotic lesions 140 1990
 
LUTHER MEDICAL PRODUCTS, INC. (1)
4,950,256 Non-thrombogenic intravascular time release catheter 72 1990
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
4,732,930 Reversible, discontinuous volume changes of ionized isopropylacrylamide cells 71 1985
 
MEDICAL RESEARCH ASSOCIATES, LTD., #2, 12707 U.S. 19 SOUTH CLEARWATER, FLA. 33516 A LIMITED PARTNERSHIP OF FLA. (1)
4,481,323 Hydrocarbon block copolymer with dispersed polysiloxane 72 1981
 
MEDTRONIC AVE, INC. (1)
5,026,607 Medical apparatus having protective, lubricious coating 130 1989
 
MEDTRONIC, INC. (1)
5,102,402 Releasable coatings on balloon catheters 228 1991
 
SCHNEIDER (EUROPE) A.G. (1)
5,163,906 Dilatation catheter and method for widening of strictures 112 1992
 
SHERWOOD SERVICES AG (1)
4,330,497 Method of making grooved plastic medical tubing 54 1981
 
THE BETH ISRAEL HOSPITAL ASSOCIATION (1)
4,909,258 Internal mammary artery (IMA) catheter 86 1988
 
THE KENDALL COMPANY (1)
4,784,647 Catheter meatal pad device 40 1986
 
UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (1)
5,091,205 Hydrophilic lubricious coatings 256 1989
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
4,364,392 Detachable balloon catheter 143 1980
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (8)
4,299,226 Coronary dilation method 187 1979
4,423,725 Multiple surgical cuff 421 1982
4,592,340 Artificial catheter means 186 1984
4,693,243 Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas 116 1986
4,820,270 Balloon catheter and process for the manufacture thereof 69 1987
4,983,166 Balloon catheter and method of use of the same 52 1990
5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 176 1990
5,232,444 Dilatation catheter 230 1991

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (48)
6,613,025 Method and apparatus for diagnostic and therapeutic agent delivery 7 2000
8,211,455 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 0 2002
7,939,094 Multiphase polymeric drug release region 3 2002
7,105,175 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 13 2002
7,060,051 Multi-balloon catheter with hydrogel coating 56 2002
7,066,904 Triggered release hydrogel drug delivery system 29 2002
7,491,234 Medical devices for delivery of therapeutic agents 15 2002
8,313,759 Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent 0 2003
7,241,455 Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent 6 2003
7,762,996 Method and apparatus for diagnostic and therapeutic agent delivery 0 2003
7,914,805 Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent 0 2003
7,357,940 Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents 3 2003
8,089,029 Bioabsorbable metal medical device and method of manufacture 0 2006
8,187,620 Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents 0 2006
8,048,150 Endoprosthesis having a fiber meshwork disposed thereon 1 2006
7,901,702 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 0 2006
8,067,054 Stents with ceramic drug reservoir layer and methods of making and using the same 0 2007
7,976,915 Endoprosthesis with select ceramic morphology 0 2007
7,381,418 Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent 7 2007
8,002,823 Endoprosthesis coating 0 2007
7,942,926 Endoprosthesis coating 0 2007
7,931,683 Articles having ceramic coated surfaces 5 2007
8,052,743 Endoprosthesis with three-dimensional disintegration control 0 2007
8,353,949 Medical devices with drug-eluting coating 0 2007
8,052,744 Medical devices and methods of making the same 0 2007
8,052,745 Endoprosthesis 0 2007
8,002,821 Bioerodible metallic ENDOPROSTHESES 3 2007
8,128,689 Bioerodible endoprosthesis with biostable inorganic layers 0 2007
8,057,534 Bioerodible endoprostheses and methods of making the same 2 2007
7,981,150 Endoprosthesis with coatings 1 2007
8,216,632 Endoprosthesis coating 0 2007
8,029,554 Stent with embedded material 1 2007
7,938,855 Deformable underlayer for stent 1 2007
8,080,055 Bioerodible endoprostheses and methods of making the same 0 2007
8,431,149 Coated medical devices for abluminal drug delivery 0 2008
8,070,797 Medical device with a porous surface for delivery of a therapeutic agent 1 2008
7,998,192 Endoprostheses 0 2008
8,236,046 Bioerodible endoprosthesis 0 2008
8,221,822 Medical device coating by laser cladding 0 2008
7,985,252 Bioerodible endoprosthesis 0 2008
8,333,795 Bulging balloon for bifurcation catheter assembly and methods 0 2008
8,382,824 Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides 0 2008
8,361,143 Medical devices for delivery of therapeutic agents 0 2009
8,071,156 Endoprostheses 0 2009
8,287,937 Endoprosthese 0 2009
8,231,980 Medical implants including iridium oxide 0 2009
8,267,992 Self-buffering medical implants 0 2010
8,066,763 Drug-releasing stent with ceramic-containing layer 0 2010
 
LUTONIX, INC. (10)
8,414,909 Drug releasing coatings for medical devices 0 2007
8,414,525 Drug releasing coatings for medical devices 0 2008
8,425,459 Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent 0 2008
8,414,526 Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids 0 2008
8,430,055 Methods and apparatuses for coating balloon catheters 0 2009
8,414,910 Drug releasing coatings for medical devices 0 2010
8,403,910 Drug releasing coatings for medical devices 0 2011
8,404,300 Drug releasing coatings for medical devices 0 2011
8,366,660 Drug releasing coatings for medical devices 0 2011
8,366,662 Drug releasing coatings for medical devices 0 2011
 
COVIDIEN LP (5)
8,434,487 Endotracheal cuff and technique for using the same 0 2006
8,196,584 Endotracheal cuff and technique for using the same 0 2006
8,307,830 Endotracheal cuff and technique for using the same 0 2006
7,950,393 Endotracheal cuff and technique for using the same 0 2006
8,413,659 Self-sizing adjustable endotracheal tube 0 2010
 
VITAL ACCESS CORPORATION (5)
6,656,151 Vascular access devices and systems 16 2000
6,595,941 Methods for external treatment of blood 16 2000
6,663,590 Vascular occlusal balloons and related vascular access devices and systems 27 2001
7,131,959 Apparatus and methods for occluding an access tube anastomosed to sidewall of an anatomical vessel 7 2003
7,124,570 Apparatus and methods for fluid occlusion of an access tube anastomosed to an anatomical vessel 7 2003
 
BIOSYNERGETICS, INC. (4)
6,738,661 Apparatus and methods for the controllable modification of compound concentration in a tube 10 2000
7,616,989 Manufacturing methods for an apparatus for the controllable modification of compound concentration in a tube 0 2001
6,985,770 Apparatus for the controllable modification of compound concentration in a tube 3 2001
8,317,760 Apparatus and methods for the controllable modification of compound concentration in a tube 0 2007
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (3)
8,226,603 Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 0 2008
8,049,061 Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery 0 2008
8,076,529 Expandable member formed of a fibrous matrix for intraluminal drug delivery 0 2008
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
8,172,783 Conduit system for isolation of fluids in biological tissues 0 1999
7,481,790 Vessel enlargement by arteriogenic factor delivery 0 2000
8,277,436 Vessel enlargement by arteriogenic factor delivery 0 2008
 
C.R. BARD, INC. (3)
8,337,475 Corporeal drainage system 0 2005
8,177,772 Catheter connection systems 1 2006
8,235,971 Catheter connection systems 0 2010
 
CV INGENUITY CORP. (3)
8,257,722 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2008
8,128,951 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2010
8,114,429 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 0 2010
 
BATTELLE MEMORIAL INSTITUTE (2)
6,979,464 Reversible geling co-polymer and method of making 7 1998
7,033,571 Multiple stimulus reversible hydrogels 16 2003
 
BIOCOMPATIBLES UK LIMITED (2)
6,746,686 Coated implants 18 2001
6,872,225 Local drug delivery 8 2002
 
CYTYC CORPORATION (2)
6,200,257 Catheter with permeable hydrogel membrane 63 1999
6,537,194 Catheter with permeable hydrogel membrane 19 2000
 
ETHICON, INC. (2)
6,808,518 Methods and devices for treating diseased blood vessels 12 2001
7,611,484 Methods and devices for treating diseased blood vessels 3 2004
 
ULRICH SPECK (2)
7,750,041 Preparation for the prophylaxis of restenosis 3 2001
8,257,305 Medical device for dispensing medicaments 0 2003
 
BAYER PHARMA AKTIENGESELLSCHAFT (1)
8,389,043 Preparation for restenosis prevention 0 2010
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
7,238,199 Method and apparatus for stent deployment with enhanced delivery of bioactive agents 37 2002
 
BOSTON SCIENTIFIC CORPORATION (1)
7,291,110 Catheter lesion diagnostics 2 2002
 
INTEGRATED VASCULAR INTERVENTIONAL TECHNOLOGIES (1)
7,118,546 Apparatus and methods for facilitating repeated vascular access 9 2003
 
MED INSTITUTE, INC. (1)
8,172,793 Coated medical device 3 2005
 
MICRO THERAPEUTICS, INC. (1)
6,635,027 Method and apparatus for intramural delivery of a substance 17 2000
 
ORBUSNEICH MEDICAL, INC. (1)
8,088,060 Progenitor endothelial cell capturing with a drug eluting implantable medical device 0 2006
 
PENTECH MEDICAL DEVICES LTD. (1)
7,410,498 Polymeric stents and other surgical articles 2 2001
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
8,303,643 Method and device for electrochemical formation of therapeutic species in vivo 0 2010
 
ROCHE MADISON INC. (1)
6,379,966 Intravascular delivery of non-viral nucleic acid 9 1999
 
SCIMED LIFE SYSTEMS, INC. (1)
6,409,716 Drug delivery 73 1997
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (4)
7,226,473 Treatment of stenotic regions 5 2003
8,211,085 Therapeutic device for the selective cytoreduction treatment of an obstruction in a natural lumen or passage of the human or animal body 0 2004
7,468,052 Treatment of stenotic regions 0 2007
8,439,868 Medical device for dispersing medicaments 0 2010