Antibodies to .beta.-amyloids or their derivatives and use thereof
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United States of America Patent
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Sep 21, 1999
Issued Date -
N/A
app pub date -
Dec 8, 1997
filing date -
Jan 25, 1993
priority date (Note) -
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Abstract
According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.
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