pH dependent polymer micelles
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United States of America Patent
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Sep 21, 1999
Grant Date -
N/A
app pub date -
Apr 23, 1997
filing date -
May 1, 1996
priority date (Note) -
Expired
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Abstract
The present invention relates to the use of poly(vinyl N-heterocycle)-block-poly(alkylene oxide) copolymers in micelle containing pharmaceutical formulations. The copolymers advantageously respond to pH differences in the environment to which they are exposed forming micelles at higher pH values. The micelles, which comprise a therapeutic compound and a copolymer, deliver drug in a pH dependent manner.
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