Conjugates of minor groove DNA binders with antisense oligonucleotides
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United States of America Patent
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Sep 21, 1999
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N/A
app pub date -
Jul 15, 1996
filing date -
Jul 15, 1996
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Expired
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Abstract
Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization complexes with DNA and can be used for any purpose which involves hybridizing an oligonucleotide to a DNA molecule, such as in antisense procedures. A method for enhancing oligonucleotide binding to a target is also provided. The method involves the step of hybridizing the target DNA with an oligonucleotide-peptide composition.
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