High dose liposomal aerosol formulations containing cyclosporin A or budesonide
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United States of America Patent
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Sep 28, 1999
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N/A
app pub date -
Oct 16, 1996
filing date -
Jul 3, 1996
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Abstract
The present invention provides a high dose pharmaceutical liposome aerosol composition comprising about 12-30 mg/ml of a pharmaceutical compound, and about 130-375 mg of a phospholipid/ml starting reservoir concentration. Specifically, the present invention is drawn to anti-inflammatory glucocorticoids, immunosuppressive compounds, anti-fungal compounds, antibiotic compounds, anti-viral compounds, and anti-cancer compounds delivered via a high dose liposome aerosol composition in a phospholipid. More specifically, the invention provides a high dose cyclosporin A liposome aerosol composition comprising up to about 30 mg/ml cyclosporin A in up to about 225 mg of a phospholipid/ml starting reservoir concentration. Also provided is a high dose budesonide-liposome aerosol composition comprising up to about 15 mg/ml budesonide in up to about 225 mg of a phospholipid/ml starting reservoir concentration.
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