Fluorescent polymeric sensor for the detection of creatinine
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United States of America Patent
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Sep 28, 1999
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N/A
app pub date -
Aug 5, 1997
filing date -
Aug 5, 1997
priority date (Note) -
Expired
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Abstract
The present invention provides a creatinine sensor material having a first layer of a protonated pH sensitive fluorophore immobilized in a hydrophobic polymer, wherein the fluorophore can react quantitatively with ammonia and the transducing moiety of the fluorophore is neutrally charged when deprotonated; a second layer of creatinine deiminase and a polymer; and a third layer of a polymer. The present invention also provides a method for detecting creatinine using the creatinine sensor material and optical sensing devices that incorporate the creatinine sensor material.
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