Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
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United States of America Patent
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Sep 28, 1999
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app pub date -
Sep 1, 1998
filing date -
Nov 1, 1996
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Abstract
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO.sub.n -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.cndot.) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.
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