Bispecific antibodies, methods of production and uses thereof

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United States of America Patent

PATENT NO 5959084
SERIAL NO

08480527

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates generally to the field of immunology, in particular that of antibodies and antibody productions. More specifically, this invention relates to bispecific antibodies, the hybrid hybridomas which produce them, the parent hybridomas, the production and selection of the hybridomas and hybrid hybridomas, and the purification of the bispecific antibodies. Specific examples relate to bispecific monoclonal antibodies which recognize both the human multi-drug resistance antigen, P-glycoprotein and human Fc.gamma. receptor III (hFc.gamma.RIII). These bispecific antibodies are useful in killing cancer cells.

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Patent Owner(s)

Patent OwnerAddress
CHIRON CORPORATION4650 HORTON STREET EMERYVILLE CALIFORNIA 94608 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ring, David Redwood City, CA 10 226
Shi, Tian-Xiang Pinole, CA 3 64

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