Methods and compositions for targeting the vasculature of solid tumors
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United States of America Patent
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Oct 12, 1999
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app pub date -
Dec 5, 1994
filing date -
Mar 5, 1992
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Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
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