US Patent No: 5,965,166

Number of patents in Portfolio can not be more than 2000

Directly compressible high load acetaminophen formulations

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
J. RETTENMAIER & SOEHNE GMBH + CO. KGROSENBERG16

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunter, Edward A San Diego, CA 43 524
Sherwood, Bob E Amenia, NY 43 571
Zeleznik, Joseph A Poughkeepsie, NY 15 108

Cited Art Landscape

Patent Info (Count) # Cites Year
 
FMC CORPORATION (10)
* 4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation 103 1987
* 4,980,193 Microcrystalline cellulose-based stabilizer system for dry mix instant chocolate drink 43 1989
* 5,075,115 Process for polymerizing poly(lactic acid) 102 1990
* 5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum 68 1991
* 5,338,562 Low fat spread and process for making same 23 1992
* 5,366,742 Colloidal microcrystalline cellulose and barrier dispersant composition and method for manufacture 36 1993
* 5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use 41 1994
* 5,462,761 Microcrystalline cellulose and glucomannan aggregates 31 1994
* 5,429,830 Marshmallow-type confections 39 1994
* 5,505,982 Chocolate confection 65 1995
 
ALZA CORPORATION (1)
* 4,946,685 Cellulosic dosage form 58 1988
 
BASF CORPORATION (1)
* 4,533,674 Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid 35 1983
 
BRISTOL-MYERS SQUIBB COMPANY (1)
* 4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product 57 1986
 
BUCKEYE TECHNOLOGIES INC. (1)
* 5,026,569 Cotton fiber particles for use in baked goods 19 1989
 
CP KELCO U.S., INC. (1)
* 4,911,946 Carbohydrate cream substitute 85 1988
 
CULTOR LTD. (1)
* 5,158,798 Low-calorie fat substitute 41 1991
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (1)
* 5,585,115 Pharmaceutical excipient having improved compressability 62 1995
 
J.M. SMUCKER COMPANY, THE (1)
* 5,132,128 Reduced calorie dessert topping 22 1991
 
KRAFT FOODS HOLDINGS, INC. (1)
* 5,011,701 Low calorie food products having smooth, creamy, organoleptic characteristics 73 1989
 
LIPTON, DIVISION OF CONOPCO, INC. (1)
* 5,209,942 Low fat/no fat salad dressing having mimetic functional properties fat and a process therefor 38 1991
 
MALLINCKRODT SPECIALTY CHEMICALS COMPANY, A DE CORP. (1)
* 4,631,284 Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom 20 1985
 
MERCK PATENT GMBH (1)
* 5,560,926 Process for the production of an S-ibuprofen-containing tablet 21 1994
 
NEXUS APS, A CORP. OF DENMARK (1)
* 4,748,027 Powder product and a method for its preparation 28 1985
 
NIRO HOLDING A/S (1)
* 5,030,400 Process and an apparatus for agglomeration of a powdery material 62 1990
 
PURDUE PHARMA L.P. (1)
* 5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 153 1993
 
RHODIA INC. (1)
* 4,439,453 Directly compressible acetaminophen granulation 53 1982
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
* 5,126,145 Controlled release tablet containing water soluble medicament 106 1990
 
TEVA GYOGYSZERGYAR RESZVENYTARSASAG (1)
* 5,322,698 Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure 25 1992
 
TEVA WOMEN'S HEALTH, INC. (1)
* 5,370,878 Method for preparing a direct compression granulated acetaminophen composition 17 1993
 
TOSHIBA CORPORATION (1)
4,303,846 Sintered electrode in a discharge tube 24 1980
 
Winters Canning Co. (1)
* 4,814,195 Reduced calorie peanut butter product 61 1987
 
Other [Check patent profile for assignment information] (1)
* H1229 Stabilizing agent for dry mix food products 23 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (5)
* 6,217,907 Directly compressible high load acetaminophen formulations 20 1999
* 6,391,337 Directly compressible high load acetaminophen formulations 6 2001
6,866,867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 6 2001
6,852,336 Directly compressible high load acetaminophen formulations 9 2002
7,179,488 Process for co-spray drying liquid herbal extracts with dry silicified MCC 2 2002
 
SCHERING CORPORATION (2)
* 6,335,032 Orally administrable solid dosage form 2 2000
* 6,337,090 Orally administrable solid ribavirin dosage forms and process for making them 3 2000
 
EDWARD MENDELL & CO. (1)
6,660,303 Pharmaceutical superdisintegrant 7 2000
 
JRS Pharma LP (1)
6,753,017 Process for preparing dry extracts 3 2001
 
PROCOM ONE, INC. (1)
8,513,299 Methods of using low-dose doxepin for the improvement of sleep 0 2007
* Cited By Examiner