US Patent No: 5,965,363

Number of patents in Portfolio can not be more than 2000

Methods of preparing nucleic acids for mass spectrometric analysis

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Importance

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Abstract

This invention relates to methods for screening nucleic acids for polymorphisms by analyzing amplified target nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting polymorphisms.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SEQUENOM, INC.SAN DIEGO, CA115
GENETRACE SYSTEMSMENLO PARK, CA3

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Becker, Christopher Hank Menlo Park, CA 6 440
Monforte, Joseph Albert Berkeley, CA 6 440
Shaler, Thomas Andrew Fremont, CA 7 441
Tan, Yuping Fremont, CA 28 442

Cited Art

Patent Info (Count) # Cites Year
 
SEQUENOM, INC. (4)
5,547,835 DNA sequencing by mass spectrometry 252 1994
5,622,824 DNA sequencing by mass spectrometry via exonuclease degradation 187 1995
5,605,798 DNA diagnostic based on mass spectrometry 191 1995
5,691,141 DNA sequencing by mass spectrometry 162 1995
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (3)
5,378,602 Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six 47 1991
5,369,004 Five highly informative microsatellite repeat polymorphic DNA markers 47 1992
5,468,610 Three highly informative microsatellite repeat polymorphic DNA markers 56 1993
 
MDS INC. (2)
5,625,184 Time-of-flight mass spectrometry analysis of biomolecules 131 1995
5,627,369 Time-of-flight mass spectrometry analysis of biomolecules 78 1995
 
ABB ALSTOM POWER INC. (1)
5,626,184 Sootblower 4 1995
 
BAYLOR COLLEGE OF MEDICINE (1)
5,364,759 DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats 99 1991
 
CHIRON DIAGNOSTICS CORPORATION (1)
4,775,619 Polynucleotide determination with selectable cleavage sites 165 1984
 
GENOMYX, INC. (1)
5,003,059 Determining DNA sequences by mass spectrometry 102 1988
 
MARSHFIELD CLINIC (1)
5,582,979 Length polymorphisms in (dC-dA).sub.n.(dG-dT).sub.n sequences and method of using the same 50 1994
 
MARSHFIELD MEDICAL RESEARCH FOUNDATION (1)
5,075,217 Length polymorphisms in (dC-dA).sub.n .multidot.(dG-dT).sub.n sequences 105 1989
 
NEW ENGLAND BIOLABS, INC. (1)
4,935,357 Universal restriction endonuclease 34 1986
 
PROMEGA CORPORATION (1)
5,599,666 Allelic ladders for short tandem repeat loci 24 1994
 
QUEEN'S UNIVERSITY AT KINGSTON (1)
5,508,169 Indexing linkers 128 1994
 
SRI INTERNATIONAL (1)
5,700,642 Oligonucleotide sizing using immobilized cleavable primers 149 1995
 
THE JOHNS HOPKINS UNIVERSITY (1)
5,464,985 Non-linear field reflectron 58 1993
 
THE ROCKEFELLER UNIVERSITY (1)
5,288,644 Instrument and method for the sequencing of genome 122 1992
 
TRUSTEES OF BOSTON UNIVERSITY (1)
5,503,980 Positional sequencing by hybridization 200 1994
 
WAYNE STATE UNIVERSITY (1)
5,580,733 Vaporization and sequencing of nucleic acids 120 1994
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
5,064,754 Genomic sequencing method 108 1987

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
IBIS BIOSCIENCES, INC. (40)
7,217,510 Methods for providing bacterial bioagent characterizing information 40 2001
7,108,974 Method for rapid detection and identification of bioagents 40 2002
7,781,162 Methods for rapid identification of pathogens in humans and animals 27 2003
7,666,588 Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 27 2003
7,255,992 Methods for rapid detection and identification of bioagents for environmental and product testing 41 2003
7,226,739 Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations 40 2003
7,718,354 Methods for rapid identification of pathogens in humans and animals 27 2003
8,073,627 System for indentification of pathogens 7 2004
8,057,993 Methods for identification of coronaviruses 8 2004
7,964,343 Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture 1 2004
7,811,753 Methods for repairing degraded DNA 0 2004
8,158,354 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture 4 2004
7,666,592 Methods for concurrent identification and quantification of an unknown bioagent 0 2005
8,119,336 Compositions for use in identification of alphaviruses 0 2005
7,714,275 Mass spectrometry with selective ion filtration by digital thresholding 1 2005
8,163,895 Compositions for use in identification of orthopoxviruses 0 2005
8,017,322 Method for rapid detection and identification of bioagents 8 2005
8,017,358 Method for rapid detection and identification of bioagents 8 2006
7,741,036 Method for rapid detection and identification of bioagents 31 2006
8,182,992 Compositions for use in identification of adventitious viruses 0 2006
8,026,084 Methods for rapid identification and quantitation of nucleic acid variants 8 2006
8,298,760 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 0 2007
8,394,945 Compositions for use in identification of bacteria 0 2007
8,288,523 Compositions for use in identification of bacteria 0 2007
8,242,254 Compositions for use in identification of bacteria 0 2007
7,956,175 Compositions for use in identification of bacteria 8 2007
8,013,142 Compositions for use in identification of bacteria 3 2007
8,088,582 Compositions for the use in identification of fungi 0 2007
8,097,416 Methods for identification of sepsis-causing bacteria 2 2007
8,265,878 Method for rapid detection and identification of bioagents 0 2007
8,071,309 Methods for rapid identification of pathogens in humans and animals 7 2007
8,017,743 Method for rapid detection and identification of bioagents 8 2007
8,380,442 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 0 2007
8,268,565 Methods for identifying bioagents 0 2008
8,148,163 Sample processing units, systems, and related methods 0 2009
8,084,207 Compositions for use in identification of papillomavirus 0 2009
8,187,814 Methods for concurrent identification and quantification of an unknown bioagent 0 2010
8,173,957 Mass spectrometry with selective ion filtration by digital thresholding 0 2010
8,158,936 Ionization probe assemblies 0 2010
8,252,599 Sample processing units, systems, and related methods 0 2011
 
SEQUENOM, INC. (28)
6,428,955 DNA diagnostics based on mass spectrometry 58 1996
7,285,422 Systems and methods for preparing and analyzing low volume analyte array elements 38 1997
6,635,452 Releasable nonvolatile mass label molecules 24 1997
6,566,055 Methods of preparing nucleic acids for mass spectrometric analysis 55 1998
6,949,633 Primers useful for sizing nucleic acids 9 1998
6,277,573 DNA diagnostics based on mass spectrometry 70 1999
6,258,538 DNA diagnostics based on mass spectrometry 68 1999
6,235,478 DNA diagnostics based on mass spectrometry 68 1999
6,197,498 DNA diagnostics based on mass spectrometry 78 1999
7,232,688 Systems and methods for preparing and analyzing low volume analyte array elements 4 1999
7,803,529 Solid phase sequencing of biopolymers 0 1999
6,268,144 DNA diagnostics based on mass spectrometry 101 1999
6,221,601 DNA diagnostics based on mass spectrometry 70 1999
6,300,076 DNA diagnostics based on mass spectrometry 74 2000
6,221,605 DNA diagnostics based on mass spectrometry 67 2000
6,468,748 Methods of screening nucleic acids using volatile salts in mass spectrometry 51 2000
7,198,893 DNA diagnostics based on mass spectrometry 39 2000
6,602,662 DNA diagnostics based on mass spectrometry 55 2000
6,500,621 DNA diagnostics based on mass spectrometry 54 2001
6,589,485 Solid support for mass spectrometry 54 2001
7,132,519 Releasable nonvolatile mass-label molecules 1 2002
7,332,275 Methods for detecting methylated nucleotides 2 2002
7,074,563 Mass spectrometric methods for detecting mutations in a target nucleic acid 4 2003
7,820,378 Fragmentation-based methods and systems for sequence variation detection and discovery 2 2003
7,608,394 Methods and compositions for phenotype identification based on nucleic acid methylation 0 2004
7,419,787 Mass spectrometric methods for detecting mutations in a target nucleic acid 36 2006
7,501,251 DNA diagnostics based on mass spectrometry 35 2006
7,759,065 Mass spectrometric methods for detecting mutations in a target nucleic acid 0 2008
 
RAVGEN, INC. (7)
6,977,162 Rapid analysis of variations in a genome 6 2002
7,208,274 Rapid analysis of variations in a genome 6 2003
7,332,277 Methods for detection of genetic disorders 17 2003
7,598,060 Rapid analysis of variations in a genome 0 2005
7,727,720 Methods for detection of genetic disorders 4 2005
7,442,506 Methods for detection of genetic disorders 14 2005
7,718,370 Methods for detection of genetic disorders 1 2006
 
SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (4)
7,557,779 Display device 6 2004
7,977,678 Semiconductor display device 0 2008
8,217,864 Display device 0 2009
8,294,154 Semiconductor display device 1 2011
 
CAPROTEC BIOANALYTICS GMBH (1)
7,091,046 Multiplexed protein expression and activity assay 2 2001
 
CLEVELAND STATE UNIVERSITY (1)
6,479,242 Method for genotyping of single nucleotide polymorphism 10 2000
 
DALTONIK, BRUKER (1)
6,589,735 Simple SNP analysis using mass spectrometry 0 1999
 
DRIVE SENTRY, INC. (1)
8,214,154 Systems for rapid identification of pathogens in humans and animals 0 2007
 
SCIENCE APPLICATIONS INTERNATIONAL CORPORATION (1)
8,046,171 Methods and apparatus for genetic evaluation 8 2003
 
SHINKATSU MORISAWA (1)
6,824,980 Isometric primer extension method and kit for detection and quantification of specific nucleic acid 0 2001
 
TRUSTEES OF BOSTON UNIVERSITY (1)
6,660,229 Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing 8 2001
 
UNIVERSITY OF UTAH (1)
7,083,923 High-throughput glutathione S-transferase polymorphic allele assay design 0 2001
 
VARIAGENICS, INC. (1)
6,566,059 Method for analyzing polynucleotides 22 1999