Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
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United States of America Patent
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Oct 12, 1999
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app pub date -
Sep 11, 1997
filing date -
Sep 13, 1996
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Abstract
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
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