Polymers with controlled physical state and bioerodibility
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United States of America Patent
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Oct 19, 1999
Issued Date -
N/A
app pub date -
Dec 5, 1997
filing date -
Jan 5, 1996
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Abstract
Polymers useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents are prepared in such a manner that the rate and degree to which they are hydrolyzed can be controlled without addition of exogenous acid. This control results from the incorporation of esters of short-chain .alpha.-hydroxy acids such as esters of glycolic acid, lactic acid or glycolic-co-lactic acid copolymer into the polymer chain and variation of the amount of these esters relative to the polymer as a whole.
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