Antisense oligonucleotide modulation of human HER-2 expression

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United States of America Patent

PATENT NO 5968748
SERIAL NO

09048804

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Abstract

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Compounds, compositions and methods are provided for inhibiting the expression of human HER-2 (also known as c-neu, ErbB-2 and HER-2/neu). The compositions comprise antisense oligonucleoptides targeted to nucleic acids encoding HER-2. Methods of using these oligonucleotides for inhibition of HER-2 expression and for treatment of diseases such as cancers associated with overexpression of HER-2 are provided. Methods of inhibiting other growth factor receptors using antisense oligonucleotides targeted to nucleic acids encoding HER-2 are also provided.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.;THE PENN STATE RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bennett, C Frank Carlsbad, CA 408 7381
Lipton, Allan Hershey, PA 9 222
Witters, Lois M York Haven, PA 3 110

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