Verotoxin pharmaceutical compositions and medical treatments therewith
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United States of America Patent
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Oct 19, 1999
Issued Date -
N/A
app pub date -
Nov 28, 1995
filing date -
Feb 22, 1994
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Abstract
Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1 and their pentameric subunit B, have been found to be useful in the treatment of mammalian neoplasia, particularly, brain cancer, ovarian cancer, breast cancer and skin cancer. Although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti-neoplastic in vivo. Use of a sensitizer, such as sodium butyrate, enhances the efficacy of verotoxins and their subunit B.
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