Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens
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United States of America Patent
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Oct 26, 1999
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N/A
app pub date -
Dec 5, 1994
filing date -
Apr 3, 1992
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Abstract
A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a 'motif' of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.
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