Combinatorial hydroxy-amino acid amide libraries

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United States of America Patent

PATENT NO 5972719
SERIAL NO

08743960

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Abstract

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Combinatorial chemical libraries of Formula I ##STR1## and methods for their preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. The use of the libraries to discover biologically active compounds is also disclosed.

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PHARMACOPEIA INCP O BOX 5350 PRINCETON NJ 08543-5350

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dolle, III Roland Ellwood King of Prussia, PA 27 187
Guo, Tao Somerset, NJ 115 1102
He, Zhen Min Princeton, NJ 14 172
Johnson, Jr Theodore Otto Plainsboro, NJ 7 351
Patel, Hitesh K North Brunswick, NJ 41 948
Tao, Shiwei Plainsboro, NJ 30 189

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