Inverted chimeric oligonucleotides
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United States of America Patent
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Oct 26, 1999
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N/A
app pub date -
Jul 1, 1997
filing date -
Aug 17, 1995
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Abstract
The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides inverted hybrid oligonucleotides and inverted chimeric oligonucleotides, both of which produce reduced side effects, relative to traditional phosphorothioate, hybrid or chimeric oligonucleotides.
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