Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
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United States of America Patent
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Nov 2, 1999
Issued Date -
N/A
app pub date -
Feb 28, 1997
filing date -
Mar 30, 1994
priority date (Note) -
Expired
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Abstract
The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.
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