US Patent No: 5,976,894

Number of patents in Portfolio can not be more than 2000

Combinatorial amide alcohol libraries

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Abstract

Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and -L'-Z is a linker/ligand residue. In these libraries, Z is ##STR1## and Y is --P(O)(OR.sup.6)(OR.sup.7), --CH(OH)--COR.sup.8, --CH.sub.2 CH.dbd.CH.sub.2 --CH.sub.2 CH(OH)CH.sub.2 OH, --CH.sub.2 CHO, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OC(O)NHR.sup.26, --CH.sub.2 CH.sub.2 NR.sup.27 R.sup.28, or ##STR2## The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PHARMACOPEIA DRUG DISCOVERY, INC.CRANBURY, NJ92

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cavallaro, Cullen Lee Highstown, NJ 5 17
Dolle, III Roland Ellwood King of Prussia, PA 27 112
Herpin, Timothee Felix Princeton, NJ 9 28
Shimshock, Yvonne Class Somerville, NJ 6 20

Cited Art

Patent Info (Count) # Cites Year
 
ARQULE, INC. (1)
5,712,171 Method of generating a plurality of chemical compounds in a spatially arranged array 57 1995
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
5,565,324 Complex combinatorial chemical libraries encoded with tags 252 1994

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
PHIGENIX, INC. (3)
8,080,534 Targeting PAX2 for the treatment of breast cancer 1 2010
8,431,546 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
8,394,780 Targeting PAX2 for the treatment of breast cancer 0 2011
 
PHARMACIA & UPJOHN COMPANY (2)
7,244,755 Hydroxypropylamines 9 2002
7,262,208 Hydroxypropyl amides for the treatment of Alzheimer's disease 0 2003
 
PHARMACOPEIA, INC. (2)
6,255,120 Combinatorial library of substituted statine esters and amides via a novel acid-catalyzed rearrangement 0 1998
6,191,277 Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases 4 1999
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (2)
7,964,577 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2006
8,318,692 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011