Trisubstituted thioxanthines
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United States of America Patent
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Nov 2, 1999
Issued Date -
N/A
app pub date -
Sep 15, 1997
filing date -
Dec 13, 1994
priority date (Note) -
Expired
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Abstract
Disclosed are compounds of the formula: ##STR1## wherein R.sup.1, R.sup.3 and R.sup.8 are independently alkyl, aryl or aralkyl, and R.sup.2 is selected from the group consisting of S and O, R.sup.6 is selected from the group consisting of S and O, provided that R.sup.2 and R.sup.6 are not both O. The compounds are effective PDE IV inhibitors and possess improved PDE IV inhibition and improved selectivity with regard to PDE III inhibition. Methods of treatment using the compounds are also disclosed.
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