Water soluble paclitaxel prodrugs
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United States of America Patent
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Nov 2, 1999
Grant Date -
N/A
app pub date -
Mar 11, 1997
filing date -
Mar 12, 1996
priority date (Note) -
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Abstract
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.
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