Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
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United States of America Patent
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Nov 9, 1999
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N/A
app pub date -
Jul 1, 1998
filing date -
Jul 1, 1998
priority date (Note) -
Expired
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Abstract
The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid derivatives of the glutarylpaclitaxel, all of which possess the cytotoxicity activity of the parent compound, paclitaxel. Also disclosed are fluorescent derivatives of paclitaxel for determining a concentration of paclitaxel in a medium or for detecting apoptotic cancer cells.
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