.alpha.-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
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United States of America Patent
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Nov 9, 1999
Grant Date -
N/A
app pub date -
Dec 19, 1997
filing date -
Dec 19, 1997
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Abstract
A process for preparing .alpha.-interferon-polymer conjugates having high levels of retained interferon activity and relatively long circulating lives in vivo is disclosed. The process includes forming substantially non-antigenic .alpha.-interferon-polymer conjugates, combining the .alpha.-interferon-polymer conjugates with a sufficient amount of an acid to reduce the pH of the conjugates to a level which is sufficient to cleave the polymer linkages in an active site area of the interferon and thereafter adjusting the .alpha.-interferon-polymer conjugates to a physiologically-acceptable pH. Methods of treating interferon-susceptible conditions with the compositions of the present invention are also disclosed.
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