Antisense oligonucleotide modulation of B-raf gene expression
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United States of America Patent
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Nov 9, 1999
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Jul 7, 1997
filing date -
May 31, 1994
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Abstract
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
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