Compositions and methods of use for osteoclast inhibitor factors

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United States of America Patent

PATENT NO 5985832
SERIAL NO

09139424

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ATTORNEY / AGENT: (SPONSORED)

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It has been found that two proteins produced by human osteoclasts inhibit osteoclast formation in bone marrow cultures and inhibit bone resorption in a fetal long bone assay. One of the proteins is identical to an Ly6 gene family protein and homologous to the Sca2 antigen, Ly6A. The second, OIP-2, is a novel protein not previously identified. The discovery of the osteoclast inhibition property of the OIP proteins suggests the therapeutic potential for patients with disordered osteoclast activity in such conditions as osteoporosis.

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BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEMAUSTIN TX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Sun-Jin San Antonio, TX 1 24
Reddy, Sakamuri V San Antonio, TX 3 24
Roodman, G David San Antonio, TX 9 25

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