Compositions and methods for decreasing IGIF and IFN-.gamma. production by administering an ICE inhibitor
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United States of America Patent
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Nov 16, 1999
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N/A
app pub date -
Sep 12, 1996
filing date -
Sep 12, 1996
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Abstract
The present invention relates to methods and pharmaceutical compositions for decreasing the production of interferon-gamma inducing factor (IGIF). The invention also relates to methods and pharmaceutical compositions for decreasing the production of interferon-gamma (IFN-.gamma.). The compositions comprise a therapeutically effective amount of a compound which inhibits interleukin-1.beta. converting enzyme (ICE) and a pharmaceutically acceptable carrier. The methods comprise the step of administering the above compositions to a subject. The present invention also relates to methods for treating or reducing the advancement, severity or effects of an IGIF- or IFN-.gamma.-mediated inflammatory, infectious or autoimmune condition.
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