Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI)
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United States of America Patent
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Nov 30, 1999
Grant Date -
N/A
app pub date -
Nov 7, 1997
filing date -
Nov 8, 1996
priority date (Note) -
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Abstract
Methods and products for the treatment of a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide are provided. In the methods of the invention a peptide that inhibits the activation of thrombin-activatable fibrinolysis inhibitor (TAFI) is administered in an effective amount and in a pharmaceutically acceptable carrier to a subject having a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide. The compositions are pharmaceutical compositions of peptides that inhibit the activation of TAFI. Also provided is a monoclonal antibody that binds TAFI zymogen but that does not bind to active TAFI and inhibits the activation of TAFI.
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