Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO

5994083

SERIAL NO

08553257

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Abstract

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A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist ofthe antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.RAHWAY, NJ13

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cortese, Riccardo Rome, IT 22 58
Felici, Franco Rome, IT 10 42
Luzzago, Alessandra Rome, IT 5 38
Monaci, Paolo Rome, IT 10 70
Nicosia, Alfredo Rome, IT 21 68

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 5182366 Controlled synthesis of peptide mixtures using mixed resins 122 1990
* 5492807 Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease 13 1993
 
DUKE UNIVERSITY (1)
* 4751181 Methods and compositions useful in the diagnosis and treatment of autoimmune diseases 41 1984
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
* 5010175 General method for producing and selecting peptides with specific properties 269 1988
 
AFFYMAX, INC. (2)
* 5432018 Peptide library and screening systems 163 1991
* 5270170 Peptide library and screening method 220 1991
 
DYAX CORP. (1)
* 5223409 Directed evolution of novel binding proteins 1377 1991
* Cited By Examiner

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7588766 Treatment of amyloidogenic disease 13 2000
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8535673 Prevention and treatment of amyloidogenic disease 0 2004
8034339 Prevention and treatment of amyloidogenic disease 7 2004
7790856 Humanized antibodies that recognize beta amyloid peptide 8 2006
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IRM LLC (1)
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* 2011/0081,382 TREATMENT AND PREVENTION OF TUBERCULOSIS 0 2010
 
MSD ITALIA S.R.L. (4)
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8142794 Hepatitis C virus vaccine 0 2009
* 2009/0233,992 HEPATITIS C VIRUS VACCINE 0 2009
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