US Patent No: 5,994,083

Number of patents in Portfolio can not be more than 2000

Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable

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Abstract

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A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist ofthe antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.RAHWAY, NJ47

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cortese, Riccardo Rome, IT 24 43
Felici, Franco Pomezia, IT 13 28
Luzzago, Alessandra Rome, IT 8 28
Monaci, Paolo Rome, IT 13 27
Nicosia, Alfredo Rome, IT 23 46

Cited Art Landscape

Patent Info (Count) # Cites Year
 
AFFYMAX, INC. (2)
5,432,018 Peptide library and screening systems 143 1991
5,270,170 Peptide library and screening method 212 1991
 
DUKE UNIVERSITY (1)
4,751,181 Methods and compositions useful in the diagnosis and treatment of autoimmune diseases 39 1984
 
DYAX CORP. (1)
5,223,409 Directed evolution of novel binding proteins 1048 1991
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,010,175 General method for producing and selecting peptides with specific properties 242 1988
 
Other [Check patent profile for assignment information] (2)
5,182,366 Controlled synthesis of peptide mixtures using mixed resins 122 1990
5,492,807 Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease 12 1993

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
JANSSEN ALZHEIMER IMMUNOTHERAPY (9)
7,964,192 Prevention and treatment of amyloidgenic disease 2 1999
7,588,766 Treatment of amyloidogenic disease 9 2000
7,575,880 Method of screening an antibody for activity in clearing an amyloid deposit 9 2000
8,535,673 Prevention and treatment of amyloidogenic disease 0 2004
8,034,339 Prevention and treatment of amyloidogenic disease 1 2004
7,790,856 Humanized antibodies that recognize beta amyloid peptide 5 2006
8,642,044 Prevention and treatment of amyloidogenic disease 0 2007
8,034,348 Prevention and treatment of amyloidogenic disease 0 2007
7,893,214 Humanized antibodies that recognize beta amyloid peptide 4 2007
 
WYETH LLC (7)
7,582,733 Humanized antibodies that recognize beta amyloid peptide 14 2002
7,871,615 Humanized antibodies that recognize beta amyloid peptide 6 2004
7,625,560 Humanized antibodies that recognize beta amyloid peptide 11 2005
7,700,751 Humanized antibodies that recognize β-amyloid peptide 2 2007
8,613,920 Treatment of amyloidogenic diseases 0 2007
8,128,928 Humanized antibodies that recognize beta amyloid peptide 0 2007
8,003,097 Treatment of cerebral amyloid angiopathy 0 2008
 
APPLIED IMMUNE TECHNOLOGIES (1)
8,088,569 Immunogens for treatment of neoplastic and infectious disease 0 2003
 
IMMUNITOR USA INC. (1)
7,838,006 Viral vaccine composition, process and methods of use 2 2008
 
MERCK SHARP & DOHME CORP. (1)
8,142,794 Hepatitis C virus vaccine 0 2009
 
MSD ITALIA S.R.L. (1)
7,598,362 Hepatitis C virus vaccine 5 2002
 
Other [Check patent profile for assignment information] (1)
8,784,810 Treatment of amyloidogenic diseases 0 2008

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