Hypoestoxides, derivatives and agonists thereof for use as anticancer agents

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United States of America Patent

PATENT NO 5994328
SERIAL NO

09006946

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method for inhibiting the growth of cancer cells ous tumors. The method comprises administering to a subject in need of anticancer or antitumor therapy a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR1## where: R is (i) H, PO.sub.3.sup..dbd., alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 where R.sub.2 is H, an alkali metal salt, an alkaline earth metal salt, NH.sub.4.sup.+, N.sup.+ (R.sub.3).sub.4 where R.sub.3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms, or (ii) COR.sub.1 wherein R.sub.1 is selected from the group consisting of H, (CH.sub.2).sub.n CH.sub.3, where n=0-6, (CH.sub.2).sub.n COOR.sub.2 where n=1-4 and R.sub.2 is previously defined, (CH.sub.2).sub.n N.sup.+ (R.sub.3).sub.4 wherein n=1-4, and (CH.sub.2).sub.n SO.sub.3.sup.- where n=1-4, and pharmaceutically acceptable salts thereof.

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IMMUNE MODULATION INCP O BOX 998 BLOOMINGTON CA 92316-0998

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kakkanaiah, Vellalore N Los Angeles, CA 1 2
Ojo-Amaize, Emmanuel A Glendora, CA 11 65
Okogun, Joseph I New Rochelle, NY 4 54

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