Amelioration of apomorphine adverse effects
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United States of America Patent
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Nov 30, 1999
Grant Date -
N/A
app pub date -
Aug 24, 1998
filing date -
Aug 24, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Symptoms of Parkinson's disease and psychogenic male erectile dysfunction (MED) can be ameliorated through the use of apomorphine. The adverse side effects of apomorphine administration, such as nausea, vomiting, yawning, and cardiovascular effects, can be significantly reduced by a dose escalating method of acclimatization. An initial dose of apomorphine is administered to the patient, and subsequently increased over a period of time until a final apomorphine dose in excess of a desired therapeutic dose has been received by the patient. Thereafter a therapeutic dose of apomorphine, less than the final apomorphine dose, is administered to the patient with attendant reduced side effects.
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