Peripherally active anti-hyperalgesic opiates
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United States of America Patent
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Nov 30, 1999
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app pub date -
Sep 12, 1996
filing date -
Sep 12, 1995
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Abstract
Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.
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