Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis
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United States of America Patent
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Nov 30, 1999
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N/A
app pub date -
Mar 17, 1998
filing date -
Mar 18, 1997
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Expired
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Abstract
The present invention relates to inhibition of angiogenesis and the treatment of diseases mediated by angiogenesis. Particularly, the invention relates to the inhibition of neovascularization and the treatment of cancer. The invention further relates to the use of cytochalasin derivatives for the inhibition of angiogenesis and the treatment of angiogenesis associated diseases. The invention also relates to new isoindolinone compounds, compositions containing them, and methods of inhibiting angiogenesis and treating angiogenesis associated diseases with the isoindolinone derivatives.
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