Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase
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United States of America Patent
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Dec 7, 1999
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N/A
app pub date -
Nov 27, 1996
filing date -
Dec 1, 1995
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Expired
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Abstract
Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising; (a) obtaining a solid tumor tissue sample from the patient; (b) measuring a thymidylate synthase expression level in the tissue sample; and (c) comparing the thymidylate synthase expression level with a group of standard tumor tissue samples, the standards having known thymidylate synthase expression levels and known responses to the chemotherapeutic treatment, to determine if that chemotherapeutic treatment is appropriate for the patient.
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