RNase L activators and antisense oligonucleotides effective to treat RSV infections
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United States of America Patent
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Dec 7, 1999
Grant Date -
N/A
app pub date -
Feb 14, 1997
filing date -
Feb 15, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention concerns a compounds and methods for treating infection with Respiratory Syncytial Virus. The compounds comprise an antisense portion, which is complementary to a normally single stranded portion of the RSV antigenomic strand (the mRNA strand), a linker and a oligonucleotide activator of RNase L, a ubiquitous non-specific RNase. The method comprised forming a complex of an activated RNase L and the antisense molecule. The application teaches methods of determining which portions of the RSV antigenomic strand are normally single-stranded. The application teaches that an antisense oligonucleotide having the sequence of residues 8281-8299 of the RSV genome is particularly useful to practice the invention and provides in vitro results superior to those obtainable with the conventional drug of choice, ribavirin.
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