Jet droplet device
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United States of America Patent
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-
Dec 14, 1999
Issued Date -
N/A
app pub date -
May 15, 1998
filing date -
May 17, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Devices and methods are provided for precise reduction of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate design of the capillary, orifice and piezoelectric transducer, droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject substrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
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