Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
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United States of America Patent
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Dec 14, 1999
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app pub date -
Mar 31, 1997
filing date -
Mar 31, 1997
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Abstract
A method for stimulating chondrocyte proliferation and inhibiting chondrocyte differentiation along the endochondral developmental pathway is provided comprising contacting condrocytes with an effective amount of Platelet-Derived Growth Factor (PDGF) such as PDGF-BB, PDGF-AA OR PDGF-AB in the substantial absence of growth factors which promote cell differentiation. This allows such cells to be multiplied in culture for loading onto a scaffolding material and implanting into a cartilage or bone wound.
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