Polymeric lamellar substrate particles for drug delivery
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United States of America Patent
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Dec 14, 1999
Grant Date -
N/A
app pub date -
Mar 30, 1998
filing date -
Jul 13, 1995
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably the biodegradablepolymer is at least 5% by weight crystalline. Preferred biodegradable polymers are poly(L-lactide) (L.PLA) or copolymers or blends of L.PLA. The particles are especially useful for the immobilization of antigens or allergens for vaccines.
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