Transdermal protein delivery using low-frequency sonophoresis
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United States of America Patent
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Dec 14, 1999
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app pub date -
Jul 25, 1995
filing date -
Jul 25, 1995
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Abstract
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
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