Protein-coated medical substrates for local delivery of genes and method of forming coatings on the substrates
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United States of America Patent
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Dec 21, 1999
Grant Date -
N/A
app pub date -
Nov 26, 1996
filing date -
Nov 27, 1995
priority date (Note) -
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status (Latency Note)
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Abstract
This invention is directed to an article, such as a medical device, for local delivery of genes. The article comprises a substrate coated with a cross-linked protein. The invention is also directed to a method for coating an article with cross-linked protein. An additive may be optionally incorporated into the coating. The crosslinked protein coating can strongly absorb genes. Thus, the coated article can be used to locally deliver genes to a target site. The coating of the invention exhibits excellent biocompatibility and biodegradability, and does not cause toxicity or side-effects.
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