Antisense oligonucleotides for mitogen-activated protein kinases as therapy for cancer
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United States of America Patent
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Dec 28, 1999
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N/A
app pub date -
Aug 12, 1997
filing date -
Mar 28, 1997
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Abstract
A method is disclosed for inhibiting malignant neoplastic growth of epithelial or endothelial cells in a mammal by administering to the mammal an effective amount of an oligonucleotide complementary to at least a portion of mRNA for ERK-1 or ERK-2 that is overexpressed in the mammal. The antisense oligonucleotides are administered to the mammal as a dosage unit. A method of identifying and monitoring potentially malignant neoplastic cell growth in a mammal is also disclosed.
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