Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
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United States of America Patent
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Dec 28, 1999
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app pub date -
Dec 2, 1997
filing date -
Dec 2, 1997
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Abstract
A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the tissue with an aldehyde fixative to effect cross-linking of the connective tissue protein(s) and subsequently b) contacting the tissue with a polyglycidyl ether. The treatment of the crosslinked tissue with the polyglycidyl ether serves to mitigate the tissue's propensity to undergo calcification following implantation in the body.
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