Antenatal screening for chromosomal abnormalities

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United States of America Patent

PATENT NO 6010912
SERIAL NO

08566467

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method for antenatal screening for chromosomal abnormalities in which maternal blood from a pregnant woman is measured for levels of free beta hCG and at least a second serum marker and/or precursors and metabolites of these markers and the measured levels of these markers together with the gestational age of the pregnant woman are compared to reference values at various gestational ages of the levels for free beta hCG and the second serum marker in (a) pregnant women carrying foetuses having the abnormalitie(s) subject to the screen and (b) pregnant women carrying normal foetuses, the comparison being indicative of the risk of the pregnant woman carrying a foetus with an abnormality subject to the screen characterised in that the second serum marker is pregnancy associated plasma protein A (PAPPA) and the screen is carried out by the end of the thirteenth (13th) completed week of pregnancy.

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Patent Owner(s)

  • JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davies, Christopher John Caerphilly, GB 9 66

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