Methods for enhancement of protective immune responses
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United States of America Patent
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Jan 11, 2000
Issued Date -
N/A
app pub date -
Dec 12, 1997
filing date -
Apr 22, 1994
priority date (Note) -
Expired
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Abstract
Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.
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