Alkyl or olefinic endcapped polyalkylene oxide solubilizer
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United States of America Patent
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Jan 11, 2000
Issued Date -
N/A
app pub date -
Jul 21, 1997
filing date -
Jun 2, 1994
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Abstract
A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polymer which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.
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