Systematic evolution of ligands by exponential enrichment: tissue SELEX
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United States of America Patent
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Jan 11, 2000
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N/A
app pub date -
Aug 5, 1997
filing date -
May 3, 1995
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Abstract
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, endothelia of the blood brain and CSF-blood barriers, glioblastomas, and lymphomas are described.
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