CDC37 cell-cycle regulatory protein and uses related thereto
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United States of America Patent
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Jan 18, 2000
Issued Date -
N/A
app pub date -
May 9, 1997
filing date -
Jun 2, 1994
priority date (Note) -
Expired
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Abstract
The present invention relates to the discovery in mammalian cells, particularly human cells, of a novel CDK-binding protein, referred to herein as 'cdc37'. As described herein, this protein functions to facilitate activation and accordingly finctions in the modulation of cell-cycle progression, and therefore ultimately of cell growth and differentiation. Moreover, binding data indicated that cdc37 may function coordinately with other cell-cycle regulatory proteins, such as of cyclin-dependent kinases (CDKs), src, p53 and erk kinases.
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